| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Melatonin | 📋 | ✍ | ⛔ | | 38534314 | Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 38490827 | The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients |
| Valerian Root | 📋 | ✍ | ⛔ | | 37899385 | Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study |
| Ashwagandha | 📋 | ✍ | ⛔ | | 36561228 | Regulation of pro and anti-inflammatory signaling molecules in effect of Withania Somnifera root extract treated sleep deprivation induced Wistar rats |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38414320 | Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review |
| Caffeine | 📋 | ✍ | ⛔ | | 37889643 | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| Cannabidiol | 📋 | ✍ | ⛔ | | 37836465 | Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity |
| Curcumin | 📋 | ✍ | ⛔ | | 38089741 | Curcumin mitigates the sleep-deprivation impacts on rat hypothalamic paraventricular nucleus |
| Saffron | 📋 | ✍ | ⛔ | | 37484523 | Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials |
| 5-HTP | 📋 | ✍ | ⛔ | | 38309227 | The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial |
| GABA | 📋 | ✍ | ⛔ | | 38321713 | GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38236060 | Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway |
| Nobiletin | 📋 | ✍ | | | 37327385 | The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling |
| Magnesium | 📋 | ✍ | ⛔ | | 38259397 | Serum Calcium and Magnesium Levels, Not 25-Hydroxyvitamin D, Are Associated With Sleep Quality in Airline Pilots |
| Crocin | 📋 | ✍ | ⛔ | | 38567447 | Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats |
| Resveratrol | 📋 | ✍ | ⛔ | | 38501767 | Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 37808488 | The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005-2008 |
| Cherry | 📋 | | ⛔ | | 28901958 | Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms |
| Cocoa | 📋 | ✍ | ⛔ | | 32801469 | Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion |
| Food | 📋 | | | | 36694494 | Nutritional Elements in Sleep |
| Ginseng | 📋 | ✍ | ⛔ | | 34604348 | Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway |
| Kiwifruit | 📋 | ✍ | ⛔ | | 37242157 | The Impact of Kiwifruit Consumption on the Sleep and Recovery of Elite Athletes |
| L-Theanine | 📋 | ✍ | ⛔ | | 37242260 | Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 34924776 | Dietary Tryptophan and the Risk of Metabolic Syndrome: Total Effect and Mediation Effect of Sleep Duration |
| Lavender | 📋 | ✍ | ⛔ | | 35412693 | A critical review on clinical evidence of the efficacy of lavender in sleep disorders |
| Lemon Balm | 📋 | ✍ | ⛔ | | 33465795 | The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial |
| Lotus | 📋 | | ⛔ | | 35840545 | Sleep-promoting activity of lotus ( Nelumbo nucifera) rhizome water extract via GABA A receptors |
| Medicinal Plants | 📋 | | | | 34116572 | Medicinal Plants for Insomnia Related to Anxiety: An Updated Review |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 37334912 | Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome |
| Poria Mushrooms | 📋 | ✍ | | | 38657467 | Bioactive compounds from Ocimum tenuiflorum and Poria cocos: A novel natural Compound for insomnia treatment based on A computational approach |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38295659 | Pterostilbene targets the molecular oscillator RORγ to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38599059 | Vitamin B6 alleviates chronic sleep deprivation-induced hippocampal ferroptosis through CBS/GSH/GPX4 pathway |
| Vitamin C | 📋 | ✍ | ⛔ | | 38678062 | Association between vitamin C in serum and trouble sleeping based on NHANES 2017-2018 |
| Crocetin | 📋 | | | | 30477864 | Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study |
| Essential Oils | 📋 | | ⛔ | | 35836211 | Aromatherapy with single essential oils can significantly improve the sleep quality of cancer patients: a meta-analysis |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 34820541 | The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 36678548 | Long-Term Sleep Deprivation-Induced Myocardial Remodeling and Mitochondrial Dysfunction in Mice Were Attenuated by Lipoic Acid and N-Acetylcysteine |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38720773 | Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease |
| TUDCA | 📋 | ✍ | ⛔ | | 32299413 | Attenuation of intermittent hypoxia-induced apoptosis and fibrosis in pulmonary tissues via suppression of ER stress activation |
| Aloe Vera | 📋 | ✍ | ⛔ | | 27610170 | Study of Sedative-Hypnotic Effects of Aloe Vera L. Aqueous Extract Through Behavioral Evaluations and EEG Recording in Rats |
| Astragalosides | 📋 | ✍ | ⛔ | | 32306464 | Astragaloside IV Attenuates Chronic Intermittent Hypoxia-Induced Myocardial Injury by Modulating Ca 2+ Homeostasis |
| Basil | 📋 | ✍ | ⛔ | | 36750371 | The effect of oral capsule of Ocimum basilicum leaf extract on sleep quality and insomnia severity in menopausal women: A randomized clinical trial |
| BCAA | 📋 | ✍ | ⛔ | | 37237271 | The relationship between the intake of branched-chain and aromatic amino acids and individuals' sleep quality based on body mass index, gender, and age |
| Beets | 📋 | ✍ | ⛔ | | 33790676 | Effect of Dietary Nitrate Supplementation on Sleep in Chronic Obstructive Pulmonary Disease Patients |
| Berberine | 📋 | ✍ | ⛔ | | 34467691 | [Potential targets of Euodiae Fructus in treatment of insomnia based on network pharmacology] |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 38490827 | The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients |
| Calcium | 📋 | ✍ | ⛔ | | 38366270 | Effects of vitamin D and/or calcium intervention on sleep quality in individuals with prediabetes: a post hoc analysis of a randomized controlled trial |
| Carotenoids | 📋 | ✍ | ⛔ | | 38062512 | Relationship between dietary carotenoid intake and sleep duration in American adults: a population-based study |
| Chamomile | 📋 | ✍ | ⛔ | | 31006899 | Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 36912030 | Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment |
| Cinnamon | 📋 | ✍ | ⛔ | | 36317999 | The Potential of Cinnamon Extract (Cinnamomum burmanii) as Anti-insomnia Medication through Hypothalamus Pituitary Adrenal Axis Improvement in Rats |
| Citicoline | 📋 | ✍ | ⛔ | | 35911643 | Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats |
| EGCG | 📋 | ✍ | ⛔ | | 34820541 | The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 36235788 | Effect of Docosahexaenoic Acid and Eicosapentaenoic Acid Supplementation on Sleep Quality in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 37101588 | An integrated targeted metabolomics and network pharmacology approach to exploring the mechanism of ellagic acid against sleep deprivation-induced memory impairment and anxiety |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 34790730 | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
| Genistein | 📋 | ✍ | ⛔ | | 37108207 | Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 35215423 | Time-of-Day Circadian Modulation of Grape-Seed Procyanidin Extract (GSPE) in Hepatic Mitochondrial Dynamics in Cafeteria-Diet-Induced Obese Rats |
| Hesperidin | 📋 | ✍ | ⛔ | | 36387348 | Fourteen-Day Evolution of COVID-19 Symptoms during the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study |
| Honeysuckle | 📋 | | ⛔ | | 35495054 | Lonicerae Japonicae Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice |
| Iron | 📋 | ✍ | ⛔ | | 24198314 | Treatment of pediatric restless legs syndrome |
| L-Carnitine | 📋 | ✍ | ⛔ | | 35273778 | Impact of L-carnitine in narcolepsy treatment: a systematic review on the effectiveness and safety |
| L-Histidine | 📋 | ✍ | ⛔ | | 35429681 | Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice |
| Lemon Verbena | 📋 | | ⛔ | | 35011093 | Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract |
| Luteolin | 📋 | ✍ | ⛔ | | 36379383 | Dose-dependent manner of luteolin in the modulation of spatial memory with respect to the hippocampal level of HSP70 and HSP90 in sleep-deprived rats |
| Metformin | 📋 | ✍ | ⛔ | | 37829735 | Sleep behavior and daily activity levels in people with metabolic syndrome: effect of 1 year of metformin treatment |
| Micronutrients | 📋 | | ⛔ | | 33441476 | Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 35587996 | Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism |
| Naringenin | 📋 | ✍ | ⛔ | | 33599956 | Naringenin Ameliorates Chronic Sleep Deprivation-Induced Pain via Sirtuin1 Inhibition |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 35855386 | The Impact of Aromatherapy with Citrus Aurantium Essential Oil on Sleep Quality in Pregnant Women with Sleep Disorders: A Randomized Controlled Clinical Trial |
| Oleic Acid | 📋 | | ⛔ | | 36435269 | Oleic acid regulates the circadian rhythm of adipose tissue in obesity |
| Oolong Tea | 📋 | | ⛔ | | 31583884 | Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33838094 | The effects of foot massage on hemodialysis patients' sleep quality and restless leg syndrome: a comparison of lavender and sweet orange essential oil topical application |
| Persimmon | 📋 | | ⛔ | | 33869965 | In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from Diospyros kaki (Persimmon) |
| Procyanidins | 📋 | | ⛔ | | 28901958 | Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms |
| Progesterone | 📋 | ✍ | ⛔ | | 35102100 | Different regimens of menopausal hormone therapy for improving sleep quality: a systematic review and meta-analysis |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 35475616 | Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism |
| Rosemary | 📋 | ✍ | ⛔ | | 37532071 | Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia |
| Schisandra | 📋 | ✍ | ⛔ | | 34911135 | Raw and wine processed Schisandra chinensis regulate NREM-sleep and alleviate cardiovascular dysfunction associated with insomnia by modulating HPA Axis |
| Schisandrins | 📋 | | | | 33093880 | Schisandrin B exerts hypnotic effects in PCPA-treated rats by increasing hypothalamic 5-HT and γ-aminobutyric acid levels |
| Selenium | 📋 | ✍ | ⛔ | | 34871651 | Evaluating the Effect of Selenium on Spatial Memory Impairment Induced by Sleep Deprivation |
| Sulforaphane | 📋 | ✍ | ⛔ | | 35401114 | Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice via Augmenting Nrf2 Nuclear Translocation and Autophagy |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 37968729 | Eurycoma longifolia (Tongkat Ali) enhances wakefulness during active periods but facilitates sleep during resting periods in C57BL/6 mice |
| Turmeric | 📋 | ✍ | ⛔ | | 34003596 | A Novel Potent Sleep-promoting Effect of Turmeric: Turmeric Increases Non-rapid Eye Movement Sleep in Mice Via H 1 -receptor Blockade |
| Urolithins | 📋 | | | | 38468112 | Urolithin A Ameliorates Athletic Ability and Intestinal Microbiota in Sleep Deprivation from the Perspective of the Gut-Muscle Axis |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 36401952 | Possible association between vitamin B12 deficiency and restless legs syndrome |
| Vitamin E | 📋 | ✍ | ⛔ | | 36904186 | Effect of Vitamin E Supplementation on Chronic Insomnia Disorder in Postmenopausal Women: A Prospective, Double-Blinded Randomized Controlled Trial |
| Walnut | 📋 | | ⛔ | | 34763469 | The combined use of gamma-aminobutyric acid and walnut peptide enhances sleep in mice |
| Angelica | 📋 | ✍ | ⛔ | | 30482676 | Three-Component Herbal Tea Alleviates Prolonged Fatigue and Improves Sleep Quality: A Randomized Controlled Pilot Study |
| Apigenin | 📋 | ✍ | ⛔ | | 38476603 | Apigenin: a natural molecule at the intersection of sleep and aging |
| Apple Polyphenols | 📋 | | ⛔ | | 35174840 | Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice |
| Astaxanthin | 📋 | ✍ | ⛔ | | 28019085 | Zinc-rich oysters as well as zinc-yeast- and astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals |
| Astragalus Root | 📋 | ✍ | ⛔ | | 30482676 | Three-Component Herbal Tea Alleviates Prolonged Fatigue and Improves Sleep Quality: A Randomized Controlled Pilot Study |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 34119170 | Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota |
| Bitter Orange | 📋 | ✍ | ⛔ | | 28749734 | Comparison of the effect of lavender and bitter orange on sleep quality in postmenopausal women: A triple-blind, randomized, controlled clinical trial |
| Black Pepper | 📋 | ✍ | ⛔ | | 35684048 | Effect of Black Pepper ( Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice |
| Bromelain | 📋 | ✍ | ⛔ | | 26971528 | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
| Camphor Essential Oil | 📋 | | ⛔ | | 35691835 | A Study on the Mechanism of the Sedative-hypnotic Effect of Cinnamomum camphora chvar. Borneol Essential Oil Based on Network Pharmacology |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 37995532 | Chlorogenic acid improves the cognitive deficits of sleep-deprived mice via regulation of immunity function and intestinal flora |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36986039 | Chrysanthemum morifolium and Its Bioactive Substance Enhanced the Sleep Quality in Rodent Models via Cl- Channel Activation |
| Coffee | 📋 | ✍ | ⛔ | | 35283829 | The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats |
| Collagen | 📋 | ✍ | | | 37874350 | Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints |
| Copper | 📋 | ✍ | ⛔ | | 34453310 | Associations of Serum Zinc, Copper, and Zinc/Copper Ratio with Sleep Duration in Adults |
| Dairy | 📋 | | | | 36774251 | Exploring the Role of Dairy Products In Sleep Quality: From Population Studies to Mechanistic Evaluations |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 30876981 | Dihydromyricetin ameliorates memory impairment induced by acute sleep deprivation |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 36235788 | Effect of Docosahexaenoic Acid and Eicosapentaenoic Acid Supplementation on Sleep Quality in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Fiber | 📋 | ✍ | ⛔ | | 36373848 | Dietary fiber ameliorates sleep disturbance connected to the gut-brain axis |
| Fish Oil | 📋 | ✍ | ⛔ | | 35170619 | Fish oil ameliorates neuropsychiatric behaviors and gut dysbiosis by elevating selected microbiota-derived metabolites and tissue tight junctions in rats under chronic sleep deprivation |
| Folate | 📋 | ✍ | ⛔ | | 17604457 | Restless legs syndrome: pathophysiology and the role of iron and folate |
| Gallic Acid | 📋 | | ⛔ | | 37749929 | Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect |
| Gardenia | 📋 | | ⛔ | | 37377643 | Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota |
| Giloy | 📋 | ✍ | ⛔ | | 35230647 | Acute Sleep Deprivation-Induced Anxiety and Disruption of Hypothalamic Cell Survival and Plasticity: A Mechanistic Study of Protection by Butanol Extract of Tinospora cordifolia |
| Hawthorn | 📋 | ✍ | ⛔ | | 38249078 | Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin |
| Holy Basil | 📋 | ✍ | ⛔ | | 38657467 | Bioactive compounds from Ocimum tenuiflorum and Poria cocos: A novel natural Compound for insomnia treatment based on A computational approach |
| Hops | 📋 | ✍ | ⛔ | | 34741379 | Effect of non-alcoholic beer containing matured hop bitter acids on mood states in healthy adults: A single-arm pilot study |
| Inulin | 📋 | ✍ | ⛔ | | 33233118 | Prebiotic supplementation (beta-glucan and inulin) attenuates circadian misalignment induced by shifted light-dark cycle in mice by modulating circadian gene expression |
| Irisin | 📋 | | | | 37950099 | The role of irisin in predicting obstructive sleep apnea severity among obese individuals: a comparative analysis |
| Jujube | 📋 | | ⛔ | | 37569133 | Sleep-Enhancing Effect of Water Extract from Jujube ( Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32 |
| Kaempferol | 📋 | ✍ | ⛔ | | 38093836 | Therapeutic Potential of Kaempferol against Sleep Deprivation-Induced Cognitive Impairment: Modulation of Neuroinflammation and Synaptic Plasticity Disruption in Mice |
| Kava Root | 📋 | ✍ | ⛔ | | 11536390 | Kava and valerian in the treatment of stress-induced insomnia |
| L-Arginine | 📋 | ✍ | ⛔ | | 18058820 | Variants in the Neuronal Nitric Oxide Synthase (nNOS, NOS1) Gene Are Associated With Restless Legs Syndrome |
| L-Citrulline | 📋 | ✍ | ⛔ | | 36552534 | L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome |
| L-Glutamine | 📋 | ✍ | ⛔ | | 35247715 | Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive dysfunction in rats |
| L-Ornithine | 📋 | ✍ | ⛔ | | 29969301 | A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock |
| L-Threonine | 📋 | ✍ | ⛔ | | 31313987 | Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive |
| Magnolia | 📋 | ✍ | ⛔ | | 19505549 | Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors |
| Manganese | 📋 | ✍ | ⛔ | | 37984743 | Manganese and sleep outcomes in US adults: results from the 2017-2020 NHANES |
| Milk | 📋 | | ⛔ | | 32884728 | Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D 3 on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial |
| Minerals | 📋 | | | | 36464094 | Associations of serum zinc, copper, and selenium with sleep disorders in the American adults: Data from NHANES 2011-2016 |
| Myricetin | 📋 | | ⛔ | | 36302617 | Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain via regulation of brain-derived neurotropic factor |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 36678548 | Long-Term Sleep Deprivation-Induced Myocardial Remodeling and Mitochondrial Dysfunction in Mice Were Attenuated by Lipoic Acid and N-Acetylcysteine |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 32369735 | NAD + Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging |
| NMN | 📋 | ✍ | ⛔ | | 36698264 | Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections |
| Onion | 📋 | ✍ | ⛔ | | 33282442 | Effects of onion extract containing concentrated cysteine sulfoxides on sleep quality: a randomized, double-blind, placebo-controlled, crossover study |
| Oyster | 📋 | | ⛔ | | 28019085 | Zinc-rich oysters as well as zinc-yeast- and astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals |
| PEA | 📋 | ✍ | ⛔ | | 34522787 | Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study |
| Peach | 📋 | | ⛔ | | 35598297 | Single-cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance |
| Peanut | 📋 | | ⛔ | | 34747100 | Flavonoid-like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability |
| Peony | 📋 | | ⛔ | | 36401463 | Uncovering the mechanism of Radix Paeoniae Alba in the treatment of restless legs syndrome based on network pharmacology and molecular docking |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 32308715 | Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial |
| Pine Bark | 📋 | ✍ | ⛔ | | 35815767 | Restless legs syndrome: prevention with Pycnogenol® and improvement of the venoarteriolar response |
| Polyphenols | 📋 | | | | 36866197 | Effects of polyphenol-rich interventions on sleep disorders: A systematic review and meta-analysis |
| Pomegranate | 📋 | | ⛔ | | 27010443 | Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length |
| Postbiotics | 📋 | | | | 35815493 | Probiotics, prebiotics and postbiotics for better sleep quality: a narrative review |
| Potassium | 📋 | ✍ | ⛔ | | 23992533 | Sleep symptoms associated with intake of specific dietary nutrients |
| Prebiotics | 📋 | ✍ | ⛔ | | 35815493 | Probiotics, prebiotics and postbiotics for better sleep quality: a narrative review |
| Probiotics | 📋 | ✍ | ⛔ | | 35815493 | Probiotics, prebiotics and postbiotics for better sleep quality: a narrative review |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 34181959 | Screening out the anti-insomnia components from Prunella vulgaris L. based on plasma pharmacochemistry combined with pharmacodynamic experiments and UPLC-MS/MS analysis |
| Puerarin | 📋 | ✍ | ⛔ | | 37698689 | Puerarin alleviates sleep disorders in aged mice related to repairing intestinal mucosal barrier |
| Punicalagin | 📋 | ✍ | ⛔ | | 33834694 | Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats |
| Quercetin | 📋 | ✍ | ⛔ | | 37948027 | Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet |
| SAMe | 📋 | ✍ | ⛔ | | 35153519 | S-Adenosylmethionine May Mitigate Obstructive Sleep Apnea in an Adult with Down Syndrome: A Case Report |
| Sesamol | 📋 | | | | 33323839 | Sesamol alleviates chronic intermittent hypoxia-induced cognitive deficits via inhibiting oxidative stress and inflammation in rats |
| Skullcap | 📋 | ✍ | ⛔ | | 30068876 | Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 36528983 | Effects of sodium bicarbonate bath on the quality of sleep: An assessor-blinded, randomized, controlled, pilot clinical trial |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 35373399 | Soy isoflavones protects against cognitive deficits induced by chronic sleep deprivation via alleviating oxidative stress and suppressing neuroinflammation |
| Spikenard | 📋 | ✍ | ⛔ | | 26730138 | A comparative clinical study on the effect of Tagara (Valeriana wallichii DC.) and Jatamansi (Nardostachys jatamansi DC.) in the management of Anidra (primary insomnia) |
| Tangeretin | 📋 | | | | 28152057 | Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts |
| Tangerine | 📋 | | ⛔ | | 33096890 | Effects of Tangerine Essential Oil on Brain Waves, Moods, and Sleep Onset Latency |
| Tanshinone | 📋 | | | | 35295327 | Activation of CNR1/PI3K/AKT Pathway by Tanshinone IIA Protects Hippocampal Neurons and Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in Rats |
| Taurine | 📋 | ✍ | ⛔ | | 27857215 | Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet |
| Tea | 📋 | | | | 35266837 | Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota |
| Terpenoids | 📋 | | | | 33099224 | Modulation of cellular circadian clocks by triterpenoids |
| Theobromine | 📋 | ✍ | ⛔ | | 23992533 | Sleep symptoms associated with intake of specific dietary nutrients |
| Thyme | 📋 | ✍ | ⛔ | | 38039009 | Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial |
| Vitamin A | 📋 | ✍ | ⛔ | | 33033995 | The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 38249078 | Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 31691401 | The potential role of B5: A stitch in time and switch in cytokine |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 32933356 | The impact of myo-inositol supplementation on sleep quality in pregnant women: a randomized, double-blind, placebo-controlled study |
| Yohimbine | 📋 | ✍ | | | 19219759 | Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers |
| Zinc | 📋 | ✍ | ⛔ | | 28019085 | Zinc-rich oysters as well as zinc-yeast- and astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals |
